NEPHROGENIC ANEMIA AS A RISK FACTOR FOR THE DEVELOPMENT OF CARDIOVASCULAR DISORDERS IN CHILDREN WITH CHRONIC KIDNEY DISEASE
DOI:
https://doi.org/10.5281/zenodo.17447255Keywords:
Nephrogenic Anemia, Chronic Kidney Disease (CKD), Cardiovascular Disorders, Children, Risk Factor, Erythropoietin (EPO), Iron Deficiency, Hypertension, Left Ventricular Hypertrophy, Cardiovascular Morbidity.Abstract
A total of 260 children with chronic kidney disease (CKD) were examined. Anemia was present in 217 patients,
accounting for 83.5%, and among children with cardiovascular disorders, it was observed in 90.2% of cases (110 out of
122 patients). The interrelation between cardiovascular disorders, CKD, and anemia lies in the fact that anemia affects
the course of CKD and the development of cardiovascular pathology. Anemia in children with CKD plays a key role in
the pathogenesis of cardiovascular damage through hypoxic injury to the myocardium. Restoration of hemoglobin levels
is essential even at the early stages of CKD, as it is crucial for preventing cardiovascular complications, which are the
leading cause of death among children and adolescents with CKD.
References
Aitbaev K.A., Murkamilov I.T., Fomin V.V. Nephrogenic anemia: new physiological approaches to therapy based on
hypoxia-mimicking strategies. Almanac of Clinical Medicine. 2017 Nov; 45(7): 565–574. doi: 10.18786/2072-0505-
-45-7-565-574
Aksenova M.E. Mechanisms of cardiovascular pathology in chronic kidney disease. Practical Medicine. 2018. Vol. 16,
No. 8, pp. 21–26.
Savenkova N.D., Grigoryeva O.P. Prognosis of cardiovascular complications and renal failure in pediatric CKD patients
based on NKF-K/DOQI (2002) and KDIGO (2012) classifications. Russian Bulletin of Perinatology and Pediatrics.
; 67(2): 12–19.
Sedov D.S. Cardiac remodeling in patients with chronic kidney disease (review). Saratov Journal of Medical Scientific
Research. 2019. Vol. 15, No. 2, pp. 217–221.
Yuldashev B.A., Shamsiev A.M. Echocardiography in the diagnosis of cardiovascular disorders in children with CKD.
New Day in Medicine – 2024. No. 10 (72), pp. 159–163.
Yuldashev B.A. Pathomorphological features of myocardial remodeling depending on the progression of CKD in
children. Problems of Biology and Medicine – 2024. No. 5, pp. 270–272.
Atkinson M.A., White C.T. Hepcidin in anemia of chronic kidney disease: review for the pediatric nephrologist. Pediatr
Nephrol. 2012 Jan; 27(1): 33–40. doi: 10.1007/s00467-011-1832-y. Epub 2011 Mar 13. PMID: 2140018
Chesnaye N.C., Schaefer F., Groothoff J.W., et al. Mortality risk in European children with end-stage renal disease on
dialysis. Kidney International. 2016; 89: 1355–1362.
Gerson A., Hwang W., Fiorenza J., et al. Anemia and health-related quality of life in adolescents with chronic kidney
disease. Am J Kidney Dis. 2004 Dec; 44(6): 1017–1023. doi: 10.1053/j.ajkd.2004.08.024. PMID: 15558522
Jelkmann W. Regulation of erythropoietin production. J Physiol. 2011 Mar 15; 589 (Pt 6): 1251–1258. doi: 10.1113/
jphysiol.2010.195057. Epub 2010 Nov 15. PMID: 21078592; PMCID: PMC3082088
Mitsnefes M.M. Cardiovascular disease in children with chronic kidney disease. J Am Soc Nephrol. 2012; 23: 578–585.
Perlman R.L., Finkelstein F.O., Liu L., et al. Quality of life in chronic kidney disease (CKD): a cross-sectional analysis
in the Renal Research Institute-CKD study. Am J Kidney Dis. 2005; 45(4): 658–666. [PubMed: 15806468]